Active substance MEXIDOL
Ethylmethylhydroxypyridine succinate (Emoxypine)
N07XX Other drugs for the treatment of diseases of the nervous system
Pharmacological group MEXIDOL
The drug increases the frame's resistance to the consequences of numerous damaging factors (shock, hypoxia and ischemia, cerebral flow issues, alcohol intoxication and antipsychotic tablets - neuroleptics).
The mechanism of drug action meksidol ® because of its antioxidant, antihypoxic and membrane action. It inhibits lipid peroxidation, increases the interest of superoxide dismutase, increases the lipid-protein ratio, reduces the viscosity of the membrane, and will increase its fluidity.
Meksidol ® modulates the pastime of membrane bound enzymes (calcium-pde, adenylate cyclase, acetylcholinesterase) receptor complexes (benzodiazepine, gaba, acetylcholine), which enhances their capability to bind to ligands contributes to keeping structural and purposeful company of biological membranes, and enhance the transport of neurotransmitter synaptic transmission.
Mexidol ® increases the content of dopamine inside the brain. It reasons an boom in the compensatory activation of cardio glycolysis and a decrease in the degree of inhibition of oxidative approaches inside the krebs cycle underneath hypoxic conditions with an increase within the content material of atp and creatine phosphate, activation of the energy-synthesizing capabilities of mitochondria, and stabilization of cellular membranes.
The drug improves metabolism and blood supply to the mind, improves microcirculation and rheological homes of blood, reduces platelet aggregation.
It stabilizes the membrane systems of blood cells (erythrocytes and platelets) at some point of hemolysis. It has a hypolipidemic effect, reduces the content material of general ldl cholesterol and ldl.
The antistress effect is manifested in the normalization of publish-strain behavior, somatovegetative problems, recuperation of sleep-wakefulness cycles, impaired mastering and reminiscence tactics, discount of dystrophic and morphological modifications in numerous systems of the brain.
Mexidol ® has a said antitoxic effect in withdrawal signs and symptoms. It eliminates the neurological and neurotoxic manifestations of acute alcohol intoxication, restores behavioral disturbances, autonomic features, and is likewise able to relieve cognitive impairment as a result of long-time period ethanol intake and its cancellation.
Underneath the have an impact on of the drug mexidol ® , the impact of tranquilizing, neuroleptic, antidepressant, hypnotic and anticonvulsants is greater, which makes it possible to lessen their doses and decrease aspect outcomes.
Mexidol ® improves the practical country of the ischemic myocardium. In conditions of coronary insufficiency, it will increase the collateral blood supply to the ischemic myocardium, contributes to the renovation of the integrity of cardiomyocytes and the preservation in their useful activity. Efficiently restores myocardial contractility in reversible cardiac disorder.
It's far hastily absorbed whilst taken orally. When taken orally in doses of four hundred-500 mg c max is 3.Five-4 mcg / ml. It's miles speedy allotted in organs and tissues. The common retention time of the drug in the body whilst ingested is 4.Nine-5.2 hours.
Metabolized within the liver by means of glucuron conjugation. Five metabolites have been recognized: three-hydroxypyridine phosphate - formed inside the liver and, with the participation of alkaline phosphatase, decomposes into phosphoric acid and three-hydroxypyridine; 2nd metabolite - pharmacologically energetic, is formed in big quantities and is observed in urine on the 1st or 2d day after management; third - excreted in massive quantities inside the urine; 4th and 5th - glucuron conjugates.
T 1/2 when taken orally - 2–2.6 hours. It's far fast excreted in the urine, particularly in the shape of metabolites and in small quantities unchanged. It is maximum intensively excreted during the first four hours after taking the drug. The indicators of excretion inside the urine of unchanged drug and metabolites have individual variability.
Indicators MEXIDOL ® (Emoxypine)
Consequences of acute problems of cerebral move, incl. After brief ischemic attacks, in the segment of subcompensation as preventive guides;
Mild worrying mind harm, the effects of traumatic brain harm;
Encephalopathy of various origins (discirculatory, dysmetabolic, publish-traumatic, mixed);
Autonomic dystonia syndrome;
Moderate cognitive problems of atherosclerotic genesis;
Anxiety problems in neurotic and neurosis-like states;
Ischemic coronary heart disorder (as a part of complex remedy);
Alleviation of withdrawal signs and symptoms in alcoholism with a predominance of neurosis-like and vegetative-vascular issues, submit-withdrawal disorders;
Conditions after acute intoxication with antipsychotic drugs;
Prevention of the improvement of somatic diseases beneath the affect of severe factors and stress;
Publicity to intense (strain) elements.
Contraindications: MEXIDOL ® (Emoxypine)
Extended character sensitivity to the drug;
Acute renal failure;
Acute liver failure.
Because of insufficient information of the impact of the drug - kid's age, pregnancy, breastfeeding.
Technique of management and dosage
Inner, a hundred twenty five–250 mg 3 times a day; the maximum daily dose is 800 mg (desk 6).
The duration of treatment is two–6 weeks; for comfort of alcohol withdrawal - 5-7 days. Remedy is discontinued progressively, reducing the dose over a period of two-three days.
The initial dose is one hundred twenty five–250 mg (1–2 tablets) 1–2 times a day with a gradual growth until a therapeutic effect is obtained; the most daily dose is 800 mg (desk 6).
The duration of the path of therapy in sufferers with ihd is at the least 1.Five–2 months. Repeated publications (on the recommendation of a physician), preferably performed within the spring and autumn durations.
The advent of man or woman facet reactions of a dyspeptic or dyspeptic nature, allergies is viable.
Mexidol ® is mixed with all drugs used to treat somatic diseases.
It complements the effect of benzodiazepine tablets, antidepressants, anxiolytics, anticonvulsants, antiparkinsonian pills. Reduces the poisonous consequences of ethyl alcohol.
Symptoms: drowsiness might also increase.
Special instructions MEXIDOL
Impact on the capability to force motors or interact in different probably unsafe activities. All through the remedy duration, care have to be taken while using automobiles and engaging in different doubtlessly dangerous sports that require improved concentration of attention and speed of psychomotor reactions.
- Experience with mexidol in neurological practice
- Combined administration of mexidol with known medicines
- A modern concept of antihypoxic and antioxidant effects of mexidol
- Improvement of the efficacy of treatment of hypertensive encephalohathy by using mexidol
- Preventive therapy with mexidol in toxic damage to the heart
- The efficacy of mexidol for transient ischemic attacks in the vertebrobasilar system in elderly patients with chronic cerebral ischemia