Instructions for NOOTROPIL ® [Piracetam, Lucetam]
Pharmachologic effect Piracetam: nootropic agent. Nootropil has a fantastic effect on the metabolic techniques of the mind: it will increase the attention of atp in the mind tissue, enhances the synthesis of rna and phospholipids, stimulates glycolytic tactics, and complements the usage of glucose. Nootropil improves the integrative pastime of the mind, promotes memory consolidation, and enables the studying method. Modifications the fee of propagation of excitation in the brain, improves microcirculation, even as now not exerting a vasodilating effect, inhibits the aggregation of activated platelets. It has a defensive effect in case of brain harm due to hypoxia, intoxication, electroshock; complements alpha and beta hobby, reduces delta pastime on the eeg, reduces the severity of vestibular nystagmus. Improves connections between the cerebral hemispheres and synaptic conduction in neocortical structures, increases mental performance, improves cerebral blood go with the flow. The effect develops progressively. Nootropil has nearly no sedative and psychostimulating consequences.
Symptoms: neurology: vascular sicknesses of the brain, chronic cerebrovascular insufficiency (impaired memory, attention, speech, dizziness, headache); residual phenomena of cerebral stream problems (with the aid of ischemic type); comatose and subcomatous states (inclusive of after injuries and intoxication of the mind); convalescence (to boom motor and mental activity); illnesses of the nervous machine, accompanied through a decrease in highbrow-mnestic functions and problems of the emotional-volitional sphere (consisting of alzheimer's ailment). Psychiatry: neurotic syndrome, asthenodepressive syndrome (of diverse genesis, with a predominance of adynamia, asthenic and senesto-hypochondriacal problems, ideational inhibition within the scientific photograph); gradual disorder states (schizophrenia, psychoorganic syndrome); complex remedy: mental illnesses happening on "organically defective soil"; depressive situations resistant to antidepressants; negative tolerance of antipsychotic pills (neuroleptics), to do away with or save you the somatovegetative, neurological and intellectual complications they motive; cortical myoclonus. Narcology: alcohol withdrawal syndrome, pre- and delirious states, morphine withdrawal syndrome, acute poisoning with ethanol, morphine, barbiturates, phenamine; persistent alcoholism (with signs and symptoms of chronic issues of mental interest, asthenia, highbrow-mnestic problems). Sickle cellular anemia (as a part of mixture remedy). In pediatric practice:
Contraindications Piracetam: allergic reaction; severe renal failure (cc less than 20 ml / min), hemorrhagic stroke. With warning. Violation of hemostasis, foremost surgical interventions, heavy bleeding, being pregnant and lactation.
Aspect results Piracetam: mental agitation, motor disinhibition, irritability, imbalance, reduced ability to pay attention, anxiety, sleep disturbances, gastralgia, nausea, vomiting, constipation or diarrhea, reduced urge for food, dizziness, headache, extrapyramidal disturbances, convulsions, tremors, expanded sexual activity, worsening of angina pectoris. Side outcomes of nootropil are most usually determined at doses above 5 g / day.
Method of administration and doses: Nootropil is used orally and intravenously. Parenteral - in / in, at an initial dose of 10 g; in severe conditions - intravenous drip, within 20-30 minutes - up to 12 g / day; after improvement, the dose is gradually reduced and switched to oral administration. Inside, at the beginning of treatment - 800 mg in 3 divided doses, before meals, with the improvement of the condition, a single dose is gradually reduced to 400 mg; the duration of treatment is 6-8 weeks. The daily dose is 30-160 mg / kg, the frequency of administration is 2 times a day, if necessary, 3-4 times a day. The duration of treatment with Nootropil is from 2-3 weeks to 2-6 months. If necessary, it can be repeated after 6-8 weeks. With long-term therapy of psychoorganic syndrome in the elderly - 1.2-2.4 g / day; loading dose during the first weeks of therapy - up to 4.8 g / day. In the treatment of cerebrovascular disorders in the acute phase, it should be prescribed as early as possible, at a dose of 12 g / day for 2 weeks, and then 4.8-6 g / day. With cortical myoclonus, treatment begins with a dose of 7.2 g / day, every 3-4 days the dose is increased by 4.8 g / day until a maximum dose of 24 g / day is reached 2-3 times a day, orally or parenterally. Every 6 months, the dose should be reduced by 1.2 g every 2 days. In the treatment of dizziness, the dose is 2.4-4.8 g / day in 2-3 doses. In sickle cell anemia, the daily dose is 160 mg / kg, divided into 4 equal portions. During a crisis - up to 300 mg / kg. With alcoholism - 12 g / day during the manifestation of the ethanol withdrawal syndrome; maintenance dose - 2.4 g. In the treatment of coma, in the post-traumatic period, the initial dose is 9-12 g / day, the maintenance dose is 2.4 g, the course of treatment is 3 weeks. Children are prescribed at a dose of 30-50 mg / day. Treatment should be long-term. Solution for oral administration: daily dose - 3.3 g (8 ml of 20% solution or 5 ml of 33% solution) 2 times a day (before breakfast and dinner). Can be added to fruit juice or other drinks. In chronic renal failure with CC 50-79 ml / min, 2/3 of the usual dose is prescribed in 2-3 doses, with CC 30-49 ml / min - 1/3 dose in 2 doses, less than 30 ml / min - 1/6 of the usual dose , once.
Special instructions NOOTROPIL: it is advocated to continuously screen the signs of renal feature (mainly in sufferers with chronic renal failure) - residual nitrogen and creatinine, and in sufferers with liver illnesses - the functional state of the liver. Treatment with piracetam, if important, can be blended with the use of psychoactive, cardiovascular and other drugs. Within the treatment of acute mind lesions, it is prescribed in aggregate with different strategies of detoxification and restorative therapy, and inside the remedy of psychiatric diseases - with the corresponding psychoactive tablets. When treating patients with cortical myoclonus, abrupt discontinuation of the drug should be avoided (danger of recurrence of seizures). In case of sleep disturbances, it is advocated to cancel the nighttime consumption by adding this dose to the every day consumption. Nootropil penetrates via the filtering membranes of hemodialysis machines.
Interplay: nootropil will increase the effectiveness of thyroid hormones, antipsychotic tablets (neuroleptics), indirect anticoagulants (against the heritage of excessive doses of piracetam), psychostimulants. Whilst prescribed with neuroleptics, nootropil reduces the risk of extrapyramidal issues.