Omeprazole-Teva enteric capsules
Description
Instructions for Omeprazole-Teva enteric capsules
English Product Name
Omeprazole-Teva
Release Form
caps. enteric soluble 20 mg: 14, 28 or 30 pcs.
Description Omeprazole
Intestinal soluble white opaque solid gelatin capsules, No. 2; black ink is applied on the lid "O", on the case - "20"; capsule contents - micropellets from white to white with a yellowish or pinkish shade of color.
- Nosology (ICD codes)
- B98.0
- Helicobacter pylori as a cause of diseases classified elsewhere
- E16.4
- Disorders of gastrin secretion (hypergastrinemia, Zollinger-Ellison syndrome)
- K21.0
- Gastresophageal reflux with esophagitis
- K25
- Gastric ulcer
- K26
- Duodenal ulcer
- Y45
- Analgesic, antipyretic, and anti-inflammatory drugs
Pharmacological effect Omeprazole
omeprazole is expressed through a specific inhibition of the proton pump of gastric parietal cells, leading to a decrease in gastric acid secretion. When omeprazole is used once, prompt, reversible suppression of hydrochloric acid secretion is observed. Its mechanism of action is conversion to an active form in the acidic gastric environment, where it inhibits proton pump h+/k+-atp-ase. Omeprazole depresses hydrochloric acid synthesis, regardless of the stimulating factor, in a dose-dependent manner. Once a day, omeprazole is followed by a rapid decrease in stomach hydrochloric acid secretion, peaking after 4 days of treatment. In patients with 12-digestive ulcer disease, omeprazole 20 mg causes a steady 80% decrease in gastric acidity by 24 hours and persistently lowers the maximum gastric acid concentration after pentagastrin stimulation. Omeprazole maintains pH ≥ 3 for an average of 17 hours daily in patients with 12-digit ulcer disease. The depression of hydrochloric acid secretion depends on the area under the omeprazole concentration-time curve rather than the instantaneous concentration in the blood. Tachyphylaxis is not observed with omeprazole. Omeprazole in vitro has a bactericidal effect on Helicobacter pylori, which, when combined with antibacterial drugs, leads to rapid eradication, ulcer healing, and prolonged remission. The pharmacokinetics of omeprazole show rapid absorption from the gastrointestinal tract, with peak plasma concentrations in 1 to 2 hours. It is highly protein-bound and metabolized in the liver by cyp2c19 and cyp3a4. It is excreted primarily via the kidneys, with a half-life of about 40 minutes. Metabolism decreases minimally in older patients and, in patients with hepatic dysfunction, bioavailability of omeprazole increases. In children 1 year of age, blood concentrations of omeprazole are similar to those in adults.
Testimony Omeprazole
Adult information: Treatment and prevention of gastric and duodenal ulcers includes eradication of helicobacter pylori as part of combination therapy. Treatment and prophylaxis of NSAID-related gastric and intestinal ulcers and erosions and symptomatic gastresophageal reflux disease and acid-induced dyspepsia and Zollinger-Ellison syndrome are also being considered.
For children older than 2 years, consider treatment of reflux esophagitis and the symptoms of heartburn and belching in gastresophageal reflux if weight is equal to or greater than 20 kg. Children older than 4 years may be offered treatment for helicobacter pylori eradication of duodenal ulcer disease as part of combination therapy.
Method and modes of application Omeprazole
10 mg is taken orally once a day. It is better to take the capsules in the morning, drinking them with half a glass of water, separate from the food. Capsules should not be chewed or crushed. If swallowing is difficult, the capsule contents can be mixed with a slightly acidic liquid (juice or yogurt) for 30 minutes. If the effect is not achieved within three days, it is worth seeing a doctor. The maximum duration of treatment without consultation is 14 days. Capsules at a dosage of 20 mg and 40 mg are consumed in the morning, drinking half a glass of water separately from the food. If swallowing is difficult, the contents of the capsule can be mixed with a slightly acidic liquid for an hour and a half. For exacerbations of duodenal ulcer, 20 mg once a day for 2 weeks is recommended, and treatment can be extended for another 2 weeks if needed. People who have duodenal ulcer that does not respond well to course are usually given 40 mg once a day for 4 weeks. For patients with duodenal ulcer, 20 mg once a day is recommended as a treatment to prevent recurrences, sometimes as little as 10 mg once a day is recommended. The dose can be increased to 40 mg daily if needed. For acute gastric ulcers, 20 mg daily for 4 weeks is recommended. If the initial course of treatment does not result in complete recovery, it is worthwhile to repeat the treatment course, which takes 4 weeks. People with unresponsive gastric ulcer are usually given 40 mg daily, and recovery is usually delayed by 8 weeks. To prevent recurrences, patients with peptic ulcer disease are given 20 mg daily, increased as needed to 40 mg daily.
Regimens for Helicobacter pylori eradication of ulcer disease include omeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1000 mg simultaneously twice a day for a week; omeprazole 20 mg, clarithromycin 250 mg, metronidazole 400 mg simultaneously twice a day for a week; omeprazole 40 mg daily, amoxicillin 500 mg, metronidazole 400 mg both three times a day for a week. The recommended dose of omeprazole for eradication of Helicobacter pylori in children is 1 to 2 mg per kilogram of body weight per day. If Helicobacter pylori-positive results are available after the first course of treatment, re-course is possible. NSAID-associated gastric and duodenal ulcers are treated at a dose of 20 mg daily.
Features
- Dosage mg 0
- Expiration Date Always fresh
- Weight 80 g
Categories: GI tract and Liver
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