Pentalgin extra-gel (ketoprofen) gel

Instructions for Pentalgin extra-gel (ketoprofen) gel

Description
Transparent or semi-transparent homogeneous gel from yellowish to reddish brown with a characteristic odor. Opalescence and air bubbles may occur.

Active substances
Ketoprofen

Release Form
Gel
Composition
Composition per 1 g of gel:
The active ingredient: ketoprofen - 50.0 mg.

Extractive substances:

pepper tincture (pepper tincture) - 40.0 mg, dimethyl sulfoxide (dimexide) - 30.0 mg, camphor - 30.0 mg, pepper leaf oil mint (pepper oil) - 9.0 mg, carbomer type A - 15.0 mg, diisopropanolamide - 46.3 mg, ethanol (ethyl alcohol) 95% - 350.0 mg, purified water - up to 1000.0 mg.

"Pharmacological effect Pentalgin extra-gel

Ketoprofen is a nonsteroidal anti-inflammatory agent intended for topical use. It effectively inhibits cyclooxygenase and also reduces the activity of lipoxygenase and bradykinin. Ketoprofen also stabilizes lysosomal membranes and prevents the release of enzymes involved in the inflammatory process. The main properties of the drug are pronounced analgesic, anti-inflammatory and antipyretic action. Ketoprofen does not impair articular cartilage.

Pharmacokinetics Pentalgin extra-gel

Ketoprofen in the form of a topical gel effectively penetrates the skin depending on the physical and chemical properties of its components. The rate of release and absorption of the gel depends on its composition. The relative bioavailability of ketoprofen when topical gel is used is about 5%, which is significantly less than with oral administration. Ketoprofen in the form of a gel has an effect mainly at the local level and does not have a systemic effect.

Distribution

Ketoprofen binds well to plasma proteins (99%) and penetrates joint tissues, including synovial fluid, reaching therapeutic concentrations. The concentration of ketoprofen in the blood is insignificant. After topical gel application, the maximum plasma concentration of ketoprofen is reached in 6 hours. Considerable concentrations are present in subcutaneous fat, periarticular tissues, and synovial fluid. The drug lasts in tissues for 12 hours.

Metabolism and elimination
Ketoprofen is metabolized in the liver to form conjugates, which are excreted primarily by the kidneys. The metabolic process of ketoprofen is independent of patient age, presence of severe renal insufficiency, or cirrhosis. Ketoprofen is gradually excreted by the kidneys.

Testimony Pentalgin extra-gel

The drug is used for symptomatic treatment of the following:
- Reactive arthritis (Reiter syndrome)
- osteoarthritis of various sites,
- periarthritis, tendinitis, bursitis, myalgia, neuralgia, radiculitis,
- Musculoskeletal injuries (including sports injuries), contusions of muscles and ligaments, sprains, tears of ligaments and tendons.
The drug helps reduce pain and inflammation throughout use but does not affect the progression of the disease."

Use and dose method Pentalgin extra-gel

The berries of the gel (in volume of 3-5 cm) should be gently spread over the skin of the inflamed or painful area of the body 1-2 times a day with caution. The dosage chosen is appropriate for the area involved, based on the 5 cm gel content of 100 mg of ketoprofen.
The maximum amount of ketoprofen taken per day is 200 mg.
An occlusive dressing is not recommended.
Do not use the product without first consulting a doctor for more than 14 days.
If you accidentally miss the moment of application of the gel, you should apply it at the same time when you intend to apply the next dose, but do not double it.