Remantadine (rimantadine)

Instructions for Remantadine (rimantadine)

English product name
Remantadin

Release form
tab. 50 mg: 10, or 20 pcs.

Description

Tablets 1 tab.
rimantadine hydrochloride 50 mg

ATX codes
J05AC02 Rimantadine

Pharmacological effect rimantadine

this antiviral agent, which is a derivative of adamantane, is based on its ability to inhibit the early stage of a specific viral reproduction after entry into the cell and before RNA transcription begins. The substance has pharmacological effectiveness in inhibiting the reproduction of the virus at an early stage of the infection process. It is active against influenza A virus strains (especially A2) and tick-borne encephalitis viruses (central European and Russian spring-summer), both of which belong to the flavivirus family.

Pharmacokinetics rimantadine

this drug is the following processes. After being taken by mouth, it is absorbed slowly and almost completely in the intestine. Plasma protein binding is about 40%. The external volume of distribution is 17-25 liters per kilogram in adults and 289 liters in children. Nasal secretions are 50% above plasma levels. The maximum concentration (Cmax) is 181 ng/mL with 100 mg taken once a day and 416 ng/mL with 100 mg taken twice a day. It is metabolized by the liver. Half-life (t1/2) is 24 to 36 hours, and excretion occurs via the kidneys (unchanged 15% and hydroxyl metabolites 20%). In chronic renal failure, t1/2 is increased 2-fold. Toxic concentrations may accumulate in people with renal insufficiency and in older people unless the dose is decreased proportionally to decreased glomerular filtration.

• Nosology (ICD codes)
• J10
• Influenza due to identified seasonal influenza virus
• Z29.8
• Other specified preventive measures

Testimony rimantadine

Prevention and early treatment of influenza in adults and children over 7 years of age, prevention of influenza during epidemics in adults, prevention of tick-borne encephalitis of viral etiology.