Tanakan [Ginkgo Biloba leaf extract]

Instructions for use Tanakan [Ginkgo Biloba leaf extract]

Pharmacological properties TANAKAN

The preparation of plant origin, normalizes metabolism in cells, rheological properties of blood and microcirculation. Improves cerebral blood circulation and supply of brain tissue with oxygen and glucose, prevents aggregation of erythrocytes, inhibits platelet activating factor. It has a dose-dependent vasoregulatory effect on the vascular system, stimulates the production of an endothelium-dependent relaxing factor, dilates small arteries, increases the tone of veins, thereby regulating blood circulation in the vessels. Reduces the permeability of the vascular wall (anti-edema effect both at the level of the brain and peripheral tissues). TANAKAN

It has an antithrombotic effect (stabilizes the membranes of platelets and erythrocytes, affects the synthesis of prostaglandins, weakens the effect of biologically active substances, platelet-activating factor). Prevents the formation of free radicals and lipid peroxidation of cell membranes. Normalizes the release of neurotransmitters (norepinephrine, dopamine , acetylcholine), and their ability to bind to receptors. It has an antihypoxic effect, normalizes metabolic processes in organs and tissues, promotes the accumulation of high-energy compounds in cells, increases the utilization of oxygen and glucose, and normalizes mediator processes in the central nervous system.

The active ingredient is standardized dry ginkgo biloba extract (Egb 761): 24% heterosidives and 6% ginkgolides-bilobalides (ginkgolide A, B and bilobalide C). Ginkgo Biloba
In human studies, only the pharmacokinetic parameters of terpene fractions have been studied. When administered orally, the bioavailability of ginkgolides A, B and bilobalide C is 80–90%. The maximum concentration is reached within 1-2 hours after taking the drug TANAKAN. The half-life is about 4 hours (bilobalide, ginkgolide A) and 10 hours - (ginkgolide B).

These substances in the body do not disintegrate, they are almost completely excreted in the urine, a small amount is excreted in the feces.

Indications TANAKAN

- Cognitive deficits of various origins (discirculatory encephalopathy, due to stroke, traumatic brain injury, in old age, manifested by decreased attention, memory impairment, decreased intellectual abilities, a sense of fear, sleep disturbance), and neurosensory deficits of various origins (senile macular degeneration, diabetic retinopathy);

intermittent claudication in chronic obliterating arteriopathy of the lower extremities (II degree according to Fontaine);
visual impairment of vascular origin, a decrease in its acuity;
hearing impairment, ringing in the ears, dizziness and impaired coordination, mainly of vascular origin;
Raynaud's syndrome.

Application TANAKAN
Pills
1 tablet or 1 ml solution of 3 times a day at mealtime, drink 1 / 2 cups of water. The average duration of the course of treatment is 3 months.

Oral solution . Assign one dose (1 ml = 40 mg of pure extract) solution 3 times a day with meals. Dose should be diluted 1 / 2 cups of water. The average duration of the course of treatment is 3 months. TANAKAN

Contraindications TANAKAN
Hypersensitivity to the drug.

Side effects TANAKAN

Occasionally, the following reactions are observed:

from the gastrointestinal tract: dyspeptic symptoms, nausea, vomiting;
from the side of the central nervous system: headache, dizziness;
allergic skin reactions: redness, swelling, itching, rashes.

special instructions TANAKAN
The first signs of an improvement in the condition develop 1 month after the start of treatment.

Warning: The drug is in the form of tablets - since this drug contains lactose, it is contraindicated in patients with congenital galactosemia, glucose or galactose malabsorption syndrome, lactase deficiency.

The oral solution contains 57% ethanol, i.e. 0.45 g per dose.
Use during pregnancy and lactation. Due to the lack of clinical data during pregnancy and lactation, the use of the drug is not recommended. TANAKAN

Children. There is not enough experience regarding the use of the drug for the treatment of children.

The ability to influence the rate of reactions when driving or operating other mechanisms. During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Interactions TANAKAN
In the form of tablets - not identified.

Tanakan in the form of a solution for oral administration contains 0.45 g of ethanol per dose, so this must be taken into account when using the drug simultaneously with the following drugs Ginkgo Biloba:

- causing an antabuse effect to alcohol (the occurrence of hyperthermia, skin hyperemia, tachycardia) - disulfiram; cefamandole, cefoperazone , latamoxef (antibiotics of the cephalosporin group); chloramphenicol (antibiotic of the fenicol group); chlorpropamide, glibenclamide , glipizide , tolbutamide, (antidiabetic hypoglycemic sulfonamides); griseofulvin (antifungal drugs); 5-nitroimidazole derivatives (metronidazole, ornidazole , secnidazole , tinidazole), ketoconazole; procarbazine (cytostatics);

- drugs Ginkgo Biloba that depress the central nervous system

There is not enough experience regarding the use of the drug for the treatment of children.

The ability to influence the rate of reactions when driving or operating other mechanisms. During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.

Interactions TANAKAN
In the form of tablets - not identified.

Tanakan in the form of a solution for oral administration contains 0.45 g of ethanol per dose, so this must be taken into account when using the drug simultaneously with the following drugs Ginkgo Biloba:
causing an antabuse effect to alcohol (the occurrence of hyperthermia, skin hyperemia, tachycardia) - disulfiram; cefamandole, cefoperazone , latamoxef (antibiotics of the cephalosporin group); chloramphenicol (antibiotic of the fenicol group); chlorpropamide, glibenclamide , glipizide , tolbutamide, (antidiabetic hypoglycemic sulfonamides); griseofulvin (antifungal drugs); 5-nitroimidazole derivatives (metronidazole, ornidazole , secnidazole , tinidazole), ketoconazole; procarbazine (cytostatics);

drugs Ginkgo Biloba that depress the central nervous system